These findings using DSI and validated with reference to autoradiographic tract tracing in the monkey represent a considerable advance in the understanding of the fibre pathways in the cerebral white matter. We suggest new interpretations of the putative functions of these fibre bundles based on the cortical areas that they link. We identified 10 long association fibre bundles with DSI that match the observations in the isotope material: emanating from the parietal lobe, the superior longitudinal fasciculus subcomponents I, II and III from the occipital-parietal region, the fronto-occipital fasciculus from the temporal lobe, the middle longitudinal fasciculus and from rostral to caudal, the uncinate fasciculus, extreme capsule and arcuate fasciculus from the occipital-temporal region, the inferior longitudinal fasciculus and from the cingulate gyrus, the cingulum bundle. We then compared the results with available expositions of white matter pathways in the monkey using autoradiographic histological tract tracing. We therefore used diffusion spectrum imaging (DSI) that has the ability to resolve crossing fibres at the scale of single MRI voxels, and identified the long association tracts in the monkey brain. Diffusion tensor imaging (DTI) is able to demonstrate fibre tracts non-invasively, but present approaches have been hampered by the inability to visualize fibres that have intersecting trajectories (crossing fibres), and by the lack of a detailed map of the origins, course and terminations of the white matter pathways. National Association for Research on Schizophrenia & Affective DisordersĪssociation fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiographyUnderstanding the long association pathways that convey cortical connections is a critical step in exploring the anatomic substrates of cognition in health and disease.The journal endorses the propagation of methodological standards and will encourage database development in the field of human brain mapping. Technical advances such as novel brain imaging methods analyses for detecting or localizing neural activity synergistic uses of multiple imaging modalities strategies for the design of behavioral paradigms and neural-systems modeling are of particular interest. Article formats include original research clinical case reports technological developments theoretical articles and synthetic reviews. Brain mapping research in both normal and clinical populations is encouraged. Imaging modalities of interest include positron emission tomography event-related potentials electro-and magnetoencephalography magnetic resonance imaging and single-photon emission tomography. The journal features research derived from non-invasive brain imaging modalities used to explore the spatial and temporal organization of the neural systems supporting human behavior. Human Brain Mapping publishes peer-reviewed basic clinical technical and theoretical research in the interdisciplinary and rapidly expanding field of human brain mapping. Published by Wiley-Blackwell ISSN 1065-9471 HUM BRAIN MAPP Publication support | Impact factors